AS1517499

AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.

Product Specifications

CAS Number

[919486-40-1]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/AS1517499.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : ≥ 35 mg/mL

Smiles

O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N

Molecular Formula

C20H20ClN5O2

Molecular Weight

397.86

Precautions

H302, H312, H332

References & Citations

[1]Nagashima S, et al. Synthesis and evaluation of 2-{[2- (4-hydroxyphenyl) -ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15 (2) :1044-55.|[2]Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41 (5) :516-24.