Ursodeoxycholic acid (sodium)

Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno) deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR) . Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

Product Specifications

CAS Number

[2898-95-5]

Product Name Alternative

Ursodeoxycholate (sodium) ; Ursodiol (sodium) ; UCDA (sodium)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; FXR; G protein-coupled Bile Acid Receptor 1

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ursodeoxycholic-acid-sodium.html

Purity

99.06

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@@H]3O)C

Molecular Formula

C24H39NaO4

Molecular Weight

414.55

Precautions

H315, H319, H335

References & Citations

[1]Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16 (2) :e0246161. Published 2021 Feb 18. |[2]Goossens JF, et al. Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396.