Pregnenolone monosulfate (sodium)

Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

Product Specifications

CAS Number

[1852-38-6]

Product Name Alternative

3β-Hydroxy-5-pregnen-20-one monosulfate (sodium)

UNSPSC

12352100

Target

Autophagy; Cannabinoid Receptor; Endogenous Metabolite; TRP Channel

Type

Natural Products

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pregnenolone-monosulfate-sodium.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC([C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O

Molecular Formula

C21H31NaO5S

Molecular Weight

418.52

References & Citations

[1]Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343 (6166) :94-8.|[2] Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641 (2-3) :128-34.|[3]Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14 (1) :7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

CB1; Human Endogenous Metabolite

Citation 01

EMBO J. 2025 Aug;44 (15) :4222-4251.|Cell Metab. 2024 Nov 5;36 (11) :2402-2418.e10.|Nat Chem Biol. 2022 Nov;18 (11) :1196-1203.|Proc Natl Acad Sci U S A. 2022 Apr 12;119 (15) :e2117004119.|Sci Rep. 2025 Mar 11;15 (1) :8409.