Tiotidine
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium) . Tiotidine has low affinity for both the H1 and the H3 receptors[1][2].
Product Specifications
CAS Number
69014-14-8
Product Name Alternative
ICI 125211
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tiotidine.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CN/C(NC#N)=N\CCSCC1=CSC(NC(N)=N)=N1
Molecular Formula
C10H16N8S2
Molecular Weight
312.42
References & Citations
[1]Barth H, et al. Structural requirements of imidazole compounds to be inhibitors or activators of histaminemethyltransferase: investigation of histamine analogues and H2-receptor antagonists.|[2]Trzeciakowski JP, et al. The cardiac pharmacology of tiotidine (LCL 125, 211) : a new histamine H2-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214 (3) :629-34.|[3]Monczor F, et al. Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64 (2) :512-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; H2 Receptor; H3 Receptor
Available Sizes
Frequently Asked Questions
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