Tiotidine

Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium) . Tiotidine has low affinity for both the H1 and the H3 receptors[1][2].

Product Specifications

CAS Number

[69014-14-8]

Product Name Alternative

ICI 125211

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tiotidine.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CN/C(NC#N)=N\CCSCC1=CSC(NC(N)=N)=N1

Molecular Formula

C10H16N8S2

Molecular Weight

312.42

References & Citations

[1]Barth H, et al. Structural requirements of imidazole compounds to be inhibitors or activators of histaminemethyltransferase: investigation of histamine analogues and H2-receptor antagonists.|[2]Trzeciakowski JP, et al. The cardiac pharmacology of tiotidine (LCL 125, 211) : a new histamine H2-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214 (3) :629-34.|[3]Monczor F, et al. Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64 (2) :512-20.