Psalmotoxin 1 (TFA)

Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a) . Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease[1][3][4][6].

Product Specifications

Product Name Alternative

PcTx1 (TFA) ; Psalmopoeus cambridgei toxin-1 (TFA)

UNSPSC

12352209

Target

Apoptosis; Sodium Channel

Type

Peptides

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/psalmotoxin-1-tfa.html

Purity

99.37

Smiles

O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC5)=O)[C@@H](C)O)=O)CCCCN)=O)CCC4)=O)C(C)C)=O)=O)CC(O)=O)=O)=O)CC6=CNC=N6)=O)CCCNC(N)=N)=O)CC(N)=O)=O)C(C)C)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3C(C)C)=O)CCC(O)=O)=O)CC8=CC=CC=C8)=O)CO)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)=O)CCCCN)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCCCN)=O)CCC1)=O)[C@H](CC)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]7CCC(O)=O)=O)CC(C)C)=O)=O)CCC(O)=O)=O)=O)CC(O)=O.OC(C(F)(F)F)=O.[x]