ML 315 (hydrochloride)
Product Specifications
Product Name Alternative
Desmethyldoxepin (hydrochloride)
UNSPSC Description
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research[1].
Target Antigen
CDK; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml-315-hydrochloride.html
Purity
98.75
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
[H]Cl.ClC1=CC(CNC2=NC=NC=C2C3=CC=C4OCOC4=C3)=CC(Cl)=C1
Molecular Weight
410.68
References & Citations
[1]Coombs TC, et al. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3654-61.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117608A/ML-315-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117608A/ML-315-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2172559-91-8
Available Sizes
Curated Selection
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