ML 315 (hydrochloride)

ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research[1].

Product Specifications

CAS Number

[2172559-91-8]

Product Name Alternative

Desmethyldoxepin (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

CDK; DYRK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml-315-hydrochloride.html

Purity

98.75

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.ClC1=CC(CNC2=NC=NC=C2C3=CC=C4OCOC4=C3)=CC(Cl)=C1

Molecular Formula

C18H14Cl3N3O2

Molecular Weight

410.68

Precautions

H315, H319, H335

References & Citations

[1]Coombs TC, et al. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun 15;23 (12) :3654-61.