AP23464
AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells[1].
Product Specifications
CAS Number
[845895-51-4]
UNSPSC
12352005
Target
Apoptosis; c-Kit
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ap23464.html
Smiles
O=P(C)(C)C1=CC=C(NC2=NC(C3CCCC3)=NC4=C2N=CN4CCC5=CC(O)=CC=C5)C=C1
Molecular Formula
C26H30N5O2P
Molecular Weight
475.52
References & Citations
[1]Corbin AS, et al., In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 1;106 (1) :227-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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