Pleconaril
Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research[1][2].
Product Specifications
CAS Number
153168-05-9
Product Name Alternative
VP 63843; Win 63843
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Pleconaril.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F
Molecular Formula
C18H18F3N3O3
Molecular Weight
381.35
Precautions
H301, H413
References & Citations
[1]Benschop KS, et al. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. J Gen Virol. 2015 Mar;96 (Pt 3) :571-9.|[2]Lee JS, et al. Antiviral Activity of Itraconazole against Echovirus 30 Infection In Vitro. Osong Public Health Res Perspect. 2017 Oct;8 (5) :318-324.|[3]Zhang G, et al. In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection. Arch Virol. 2012 Apr;157 (4) :669-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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