S961
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1].
Product Specifications
CAS Number
1083433-49-1
UNSPSC
12352209
Target
Insulin Receptor
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s961.html
Purity
99.66
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(NCC(NCC(NCC(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N8[C@@H](CCC8)C(N[C@@H](CO)C(N[C@@H](CC9=CC=C(C=C9)O)C(O)=O)=O)=O)=O)NC%10=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(NCC(N[C@@H](CCCNC(N)=N)C(NC%10)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C211H295N55O71S2
Molecular Weight
4802.12
References & Citations
[1]Schäffer L, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14;376 (2) :380-3.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
J Womens Health Dev. 2023;6 (2) :56-67.|Neural Regen Res. 2021;16:2465-74.|Bioconjug Chem. 2022 May 18;33 (5) :892-906.|bioRxiv. 2025 Aug 24:2025.08.23.671589.|Neuropharmacology. 2023 Nov 1:238:109649.|SSRN. 2024 Dec 31.
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