α-Conotoxin M I

Product Specifications

CAS Number

[88217-10-1]

UNSPSC Description

α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs[1][2].

Target Antigen

mAChR; nAChR

Type

Peptides

Related Pathways

GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@@](C(N[C@H](C(N[C@@]3([H])CSSC[C@@H](C(N[C@](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC3=O)=O)CCCCN)=O)CC(N)=O)=O)CC4=CC=C(C=C4)O)=O)CO)=O)C(N)=O)([H])C(N[C@H]1CC5=CN=CN5)=O)=O)NC([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)C)=O)([H])CCC2

Molecular Weight

1493.72

References & Citations

[1]Kulak JM, et al. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997 Jul 15;17(14):5263-70. |[2]Bren N, et al. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. J Biol Chem. 2000 Apr 28;275(17):12692-700.