NSC 228155

NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM[2].

Product Specifications

CAS Number

[113104-25-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; Epigenetic Reader Domain; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC_228155.html

Purity

98.0

Solubility

DMSO : 16 mg/mL (ultrasonic)

Smiles

[O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32

Molecular Formula

C11H6N4O4S

Molecular Weight

290.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088.|[2]Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23 (19) :5371-5.