FXIIa-IN-5

FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474) -induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg) [1].

Product Specifications

CAS Number

[3047411-80-0]

UNSPSC

12352005

Target

Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fxiia-in-5.html

Smiles

O=C(C1=C2C(C=CC=C2)=C(C=C1)N3CCN(CCC3)C(C)C)N4N=C(N=C4N)C5=CC=CC=N5

Molecular Formula

C26H29N7O

Molecular Weight

455.55

References & Citations

[1]Meng Z, et al., Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation. J Med Chem. 2024 Jun 24.