Fmoc-NH-PEG2-CH2CH2COOH

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

[872679-70-4]

UNSPSC

12352203

Hazard Statement

H315, H319

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-nh-peg2-ch2ch2cooh.html

Purity

99.79

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Molecular Formula

C22H25NO6

Molecular Weight

399.44

Precautions

H315, H319

References & Citations

[1]Fulcher JM, et al. Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag. Org Biomol Chem. 2019 Dec 28;17 (48) :10237-10244.