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Anti-Mouse VISTA Antibody (13F3)

Anti-Mouse VISTA Antibody (13F3) is an anti-mouse VISTA IgG monoclonal antibody. Anti-Mouse VISTA Antibody (13F3) can reverse the immunosuppressive effect of VISTA by blocking its binding to ligands such as VSIG3. Anti-Mouse VISTA Antibody (13F3) exacerbates pulmonary fibrosis (PF) by promoting Th17 cell differentiation. Anti-Mouse VISTA Antibody (13F3) can be used for research on cancer such as breast cancer and PF[1][2].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

VISTA

Type

Inhibitory Antibodies

Related Pathways

Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-vista-antibody-13f3.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[Anti-MouseVISTAAntibody(13F3)]

Molecular Weight

(150 kDa)

References & Citations

[1]Thakkar D, et al. Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner. J Immunother Cancer. 2022 Feb;10 (2) :e003382.|[2]Xie H, et al. VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation. J Inflamm Res. 2024 Jun 19;17:3983-3999.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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