5-Methoxytryptamine (hydrochloride)

5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action[1][2][3].

Product Specifications

CAS Number

[66-83-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-methoxytryptamine-hydrochloride.html

Concentration

10mM

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCCC1=CNC2=C1C=C(OC)C=C2.[H]Cl

Molecular Formula

C11H15ClN2O

Molecular Weight

226.70

Precautions

H302, H315, H319, H335

References & Citations

[1]J Yamada, et al. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Eur J Pharmacol. 1997 Apr 4;323 (2-3) :235-40. |[2]S Bayari, et al. Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59 (6) :1255-63.|[3]D A Craig, et al. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342 (1) :9-16.