AOH1160
AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis[1].
Product Specifications
CAS Number
[2089314-57-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aoh1160.html
Purity
98.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=CC2=CC=C1)NCC(NC3=CC=CC=C3OC4=CC=CC=C4)=O
Molecular Formula
C25H20N2O3
Molecular Weight
396.44
Precautions
H302, H315, H319
References & Citations
[1]Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24 (23) :6053-6065.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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