RAF709

RAF709 is a potent, selective, and efficacious RAF inhibitor with IC50s of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively[1]. Antitumor efficacy[1].

Product Specifications

CAS Number

[1628838-42-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RAF709.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC=CC(C(F)(F)F)=C5

Molecular Formula

C28H29F3N4O4

Molecular Weight

542.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishiguchi GA, et al. Design and Discovery of N- (2-Methyl-5'-morpholino-6'- ((tetrahydro-2H-pyran-4-yl) oxy) -[3,3'-bipyridin]-5-yl) -3- (trifluoromethyl) benzamide (RAF709) : A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J Med Chem. 2017 Jun 22;60 (12) :4869-4881.