Nortriptyline-d3 (hydrochloride)

Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].

Product Specifications

CAS Number

[203784-52-5]

Product Name Alternative

Desmethylamitriptyline-d3 (hydrochloride) ; Desitriptilina-d3 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Drug Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Purity

99.69

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 7.14mg/mL (ultrasonic)

Smiles

C(CCNC([2H])([2H])[2H])=C1C=2C(CCC=3C1=CC=CC3)=CC=CC2.Cl

Molecular Formula

C19H19D3ClN

Molecular Weight

302.86

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.