D[Cha4]-AVP

D[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].

Product Specifications

CAS Number

[500170-27-4]

UNSPSC

12352209

Target

Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/d-cha4-avp.html

Purity

98.81

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O)CCC1)[C@H]2NC([C@H](CC(N)=O)NC([C@H](CC3CCCCC3)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)NC(CCSSC2)=O)=O)=O)=O)=O

Molecular Formula

C50H71N13O11S2

Molecular Weight

1094.31

References & Citations

[1]Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146 (5) :744-51.|[2]Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47 (9) :2375-88.