PF-573228
PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.
Product Specifications
CAS Number
869288-64-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; FAK
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-573228.html
Purity
99.32
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC(S(=O)(C)=O)=C4)=N3)C=C2)CC1
Molecular Formula
C22H20F3N5O3S
Molecular Weight
491.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Slack-Davis JK, et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282 (20) :14845-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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