CAY10471 (Racemate)

CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM) . CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].

Product Specifications

CAS Number

[844639-57-2]

Product Name Alternative

TM30089 (Racemate)

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H400, H410

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CAY10471_Racemate.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(O)CN1C2=C(C3=C1C=CC=C3)CC(N(S(=O)(C4=CC=C(F)C=C4)=O)C)CC2

Molecular Formula

C21H21FN2O4S

Molecular Weight

416.47

Precautions

H315, H317, H319, H400, H410

References & Citations

[1]Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48 (4) :897-900.