N, N-Dimethylglycine-d6 (hydrochloride)

N, N-Dimethylglycine-d6 (Dimethylglycine-d6) hydrochloride is the deuterium labeled N, N-Dimethylglycine hydrochloride (HY-W001158) . N, N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N, N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N, N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects[1][2][3][4].

Product Specifications

CAS Number

[347840-03-3]

Product Name Alternative

Dimethylglycine-d6 (hydrochloride) ; DMG-d6 (hydrochloride) ; N-Methylsarcosine-d6 (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Derivatives; Endogenous Metabolite; iGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Metabolic Disease; Neurological Disease

Purity

99.46

Solubility

10 mM in DMSO|DMSO : ≥ 10mg/mL

Smiles

OC(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.Cl

Molecular Formula

C4H4D6ClNO2

Molecular Weight

145.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hsieh CP, et al. N, N-dimethylglycine Protects Behavioral Disturbances and Synaptic Deficits Induced by Repeated Ketamine Exposure in Mice. Neuroscience. 2021 Sep 15;472:128-137.|[3]Bai K, et al. Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice. Int J Mol Med. 2019 May;43 (5) :2199-2211. |[4]Bai K, et al. Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice. PLoS One. 2016 May 12;11 (5) :e0155393.