Somatostatin-28 (sheep, human rat mouse)

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

Product Specifications

CAS Number

[73032-94-7]

UNSPSC

12352209

Target

Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/somatostatin-28-sheep-human-rat-mouse.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)([H])[C@H](O)C)=O)CO)=O)C(O)=O)NC(CNC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](CCSC)NC([C@H](C)NC([C@H]4N(CCC4)C([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)N[C@H]1CC7=CNC8=CC=CC=C78

Molecular Formula

C137H207N41O39S3

Molecular Weight

3148.56

References & Citations

[1]Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151 (1) :107-12. |[2]Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283 (2) :E311-7.