SDF-1α (human) (TFA)

SDF-1α (human) TFA is a mononuclear cells chemoattractant that can bind to CXCR4. SDF-1α plays a central role in stem cell homing, retention, survival, proliferation, cardiomyocyte repair, angiogenesis and ventricular remodelling following myocardial infarction. SDF-1α (human) TFA can be used in cardiovascular disease research[1][2].

Product Specifications

UNSPSC

12352209

Target

CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sdf-1α-human-tfa.html

Purity

96.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)CCCCN)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C(N2C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H]4CC(N)=O)=O)CCC3)=O)[C@@H](C)O)=O)CC(N)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCCCN)=O)CC(C)C)=O)CC5=CNC=N5)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)C)=O)CCCNC(N)=N)=O)C)=O)C(C)C)=O)CC6=CNC=N6)=O)CO)=O)CCC(O)=O)=O)CC7=CC=CC=C7)=O)CC8=CC=CC=C8)=O)CCCNC(N)=N)=O)CSSC[C@H](NC9=O)C(N[C@H](C(N[C@H](C(N%10[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(N)=O)=O)CC(C)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)CC(C)C)=O)CC%11=CC=C(O)C=C%11)=O)CCC(O)=O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC%10)=O)CC(O)=O)=O)[C@H](CC)C)=O)=O)CCC2)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]9C(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)=O)CCCNC(N)=N)=O)CC%14=CC=C(O)C=C%14)=O)CO)=O)CC(C)C)=O)CO)=O)C(C)C)=O)CCC1.O=C(O)C(F)(F)F.[x]

Molecular Formula

C356H578N106O93S4.xC2HF3O2

Molecular Weight

7959.34 (free acid)

References & Citations

[1]Gupta SK, et al. Modulation of CXCR4 expression and SDF-1alpha functional activity during differentiation of human monocytes and macrophages. J Leukoc Biol. 1999 Jul;66 (1) :135-43. |[2]Bromage DI, et al. Stromal derived factor 1α: a chemokine that delivers a two-pronged defence of the myocardium. Pharmacol Ther. 2014 Sep;143 (3) :305-15.