Amonafide
Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
Product Specifications
CAS Number
[69408-81-7]
Product Name Alternative
AS1413
UNSPSC
12352005
Hazard Statement
H302
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amonafide.html
Purity
99.92
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C
Molecular Formula
C16H17N3O2
Molecular Weight
283.33
Precautions
H302
References & Citations
[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Topo II
Available Sizes
Curated Selection
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