Amonafide

Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

Product Specifications

CAS Number

[69408-81-7]

Product Name Alternative

AS1413

UNSPSC

12352005

Hazard Statement

H302

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amonafide.html

Purity

99.92

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C

Molecular Formula

C16H17N3O2

Molecular Weight

283.33

Precautions

H302

References & Citations

[1]Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20 (7) :995-1003.|[2]Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47 (4) :1040-4.|[3]Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6 (2) :79-85.