Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

UCL 1684 (dibromide)

UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].

Product Specifications

CAS Number

199934-16-2

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ucl-1684-dibromide.html

Purity

98.07

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=[N+](CC3=CC(C[N+]4=CC=C(NCC5=CC=C(C=C5)CN6)C7=CC=CC=C47)=CC=C3)C=CC6=C1C=CC=C2.[Br-].[Br-]

Molecular Formula

C34H30Br2N4

Molecular Weight

654.44

References & Citations

[1]Burashnikov A, et al. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76 (2) :164-172.|[2]Rosa JC, et al. Bis-quinolinium cyclophanes: 6,10-diaza-3 (1,3),8 (1,4) -dibenzena-1,5 (1,4) - diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca (2+) -activated K+ channel. J Med Chem. 1998;41 (1) :2-5.|[3]Diness JG, et al. Effects on atrial fibrillation in aged hypertensive rats by Ca (2+) -activated K (+) channel inhibition. Hypertension. 2011;57 (6) :1129-1135.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Donkey Synapsin II (SYN2) ELISA Kit
MBS9352073 Inquire

Donkey Synapsin II (SYN2) ELISA Kit

Sign In for Pricing
View Details
Rabbit Polyclonal IARS2 Antibody
NBP1-84637 0.1 mL

Rabbit Polyclonal IARS2 Antibody

Sign In for Pricing
View Details
Goat Polyclonal VAV2 Antibody
NB100-895 0.1 mg

Goat Polyclonal VAV2 Antibody

Sign In for Pricing
View Details
Fibronectin/FN
E21-H38 10 µg

Fibronectin/FN

Sign In for Pricing
View Details
Slc7a6os Antibody
orb861216 2 mg

Slc7a6os Antibody

Sign In for Pricing
View Details
Mouse Monoclonal HspBP1 Antibody (OTI1D5) [Janelia Fluor 646]
NBP2-71761JF646 0.1 mL

Mouse Monoclonal HspBP1 Antibody (OTI1D5) [Janelia Fluor 646]

Sign In for Pricing
View Details