Dihydrodiol-Ibrutinib-d5
Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib. Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib[1].
Product Specifications
CAS Number
2068022-09-1
Product Name Alternative
PCI-45227-d5
UNSPSC
12352005
Target
Btk; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
NC1=C2C(N([C@@]3([H])CN(CCC3)C(C(O)CO)=O)N=C2C4=CC=C(C=C4)OC5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])=NC=N1
Molecular Formula
C25H21D5N6O4
Molecular Weight
479.54
References & Citations
[1]Sridhar Veeraraghavan, et al. Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: application to a pharmacokinetic study. J Pharm Biomed Anal
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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