PIK-90

PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.

Product Specifications

CAS Number

[677338-12-4]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

DNA-PK; PI3K

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PIK-90.html

Purity

99.70

Solubility

1 M HCl : 100 mg/mL (ultrasonic) |DMSO : 6.67 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

O=C(NC1=NC2=C(C3=NCCN13)C=CC(OC)=C2OC)C4=CC=CN=C4

Molecular Formula

C18H17N5O3

Molecular Weight

351.36

Precautions

H317, H319

References & Citations

[1]Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125 (4) :733-47.|[2]Niedermeier M, et al. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 2009 May 28;113 (22) :5549-57.|[3]Cheng CK, et al. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31;109 (31) :12722-7.