LASSBio-873
Product Specifications
UNSPSC Description
LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine[1].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lassbio-873.html
Purity
99.82
Solubility
DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1N(C2=CC=C([N+]([O-])=O)C=C2)C(C3=C1C=NC4=C3C(C)=NN4C5=CC=CC=C5)=O
Molecular Weight
399.36
References & Citations
[1]Mendes TC, et al. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clin Exp Pharmacol Physiol. 2013 Jul;40(7):404-11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157956/LASSBio-873-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157956/LASSBio-873-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
873694-54-3
Curated Selection
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