PGFRA Polyclonal Antibody

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

GAS; PDGFRA; CD140A; PDGFR-2; PDGFR2; GAS9; RHEPDGFRA; PDGF-Rα Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD_antigen: CD140a; CD140 antigen-like family member A; CD140a antigen; MGC74795; PDGF alpha chain; PDGFR 2; PDGFR alpha; PDGFRA/BCR fusion; PDGFR-alpha; PDGF-R-alpha; PGFRA; Platelet derived growth factor receptor; Platelet derived growth factor receptor 2; Platelet derived growth factor receptor alpha; Platelet derived growth factor receptor alpha polypeptide; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; platelet-derived growth factor receptor A; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor α; Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein