IRE1α kinase-IN-2
IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC50=3.12 μM) . IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines[1].
Product Specifications
CAS Number
1414938-21-8
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-2.html
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=CN2C1=C(C(C3=C4C=CC=C3)=CC=C4NC(NC5=CC(C(F)(F)F)=CC=C5)=O)N=C2C(C)C
Molecular Formula
C27H23F3N6O
Molecular Weight
504.51
References & Citations
[1]Wang L, Perera BG, Hari SB, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012;8 (12) :982-989.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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