Anti-DREAM Antibody

Rabbit Polyclonal Antibody specific to DREAM

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3

Gene Name

KCNIP3

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=KCNIP3">KCNIP3</a>

UniProt

Q9Y2W7

Cellular Locus

Cytoplasm, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Nucleus

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 26-35 of human DREAM.

Target Antigen

Calsenilin

Target

DREAM

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Protein Transcription

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {UniProtKB:Q9QXT8}.; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of rPubMed:10676964, PubMed:12829703, PubMed:15485870, PubMed:16123112, PubMed:18957440}.; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {PubMed:11259376, PubMed:11988022, PubMed:9771752}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human DREAM (31 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

The human prodynorphin gene, which is involved in memory acquisition and pain, is regulated by its downstream regulatory element (DRE) which acts as a location-dependent gene silencer. DREAM (DRE-antagonist modulator) is a transcriptional repressor. It is the first known Ca+2 binding protein that binds to DNA and regulates transcription.