Bendazol

Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats[1][2][3].

Product Specifications

CAS Number

[621-72-7]

UNSPSC

12352005

Hazard Statement

H302

Target

HIF/HIF Prolyl-Hydroxylase; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease; Others

Assay Protocol

https://www.medchemexpress.com/Bendazol.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(CC2=CC=CC=C2)=NC3=CC=CC=C3N1

Molecular Formula

C14H12N2

Molecular Weight

208.26

Precautions

H302

References & Citations

[1]Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162 (3) :357-361.|[2]Tong L, et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits. Ophthalmic Physiol Opt. 2020 Sep;40 (5) :567-576.|[3]Kuzubova EA, et al. [Effect of dibazol (bendazol) on the generative function in rats]. Eksp Klin Farmakol. 2007 Mar-Apr;70 (2) :37-9.