Tap1a
Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects[1].
Product Specifications
Product Name Alternative
Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tap1a.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC5=CNC6=CC=CC=C56)=O)CCC(N)=O)=O)CC(O)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CO)=O)=O)CO)=O)CO)=O)CC7=CC=CC=C7)=O)CCSC)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N8C(C(NC(C(NC(C(NC3CCCCN)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC8)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC9=CNC%10=CC=CC=C9%10)=O)CC(C)C)=O)CCC(N)=O)=O)CC%11=CC=C(O)C=C%11)=O)CCCCN)=O)=O)=O)CC(O)=O
Molecular Formula
C174H258N52O55S7
Molecular Weight
4182.68
References & Citations
[1]Hu H, et al. Engineering of a Spider Peptide via Conserved Structure-Function Traits Optimizes Sodium Channel Inhibition In Vitro and Anti-Nociception In Vivo. Front Mol Biosci. 2021 Sep 21;8:742457.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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