HMC1R agonist 1
(EC50=3 nM) . hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM) . hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family[1].
Product Specifications
CAS Number
3028881-87-7
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hmc1r-agonist-1.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(C)=O)CCCC)N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CSC1)=O)CC2=CNC3=C2C=CC=C3)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)CC5=CNC=N5)=O)CSCC6=CC1=CC=C6
Molecular Formula
C54H70N14O8S2
Molecular Weight
1107.35
References & Citations
[1]Nafie MS, et al. Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer. Bioorg Chem. 2022; 122:105708.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MC1R
Available Sizes
Frequently Asked Questions
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