HMC1R agonist 1

(EC50=3 nM) . hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM) . hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family[1].

Product Specifications

CAS Number

[3028881-87-7]

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hmc1r-agonist-1.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC(C)=O)CCCC)N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CSC1)=O)CC2=CNC3=C2C=CC=C3)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)CC5=CNC=N5)=O)CSCC6=CC1=CC=C6

Molecular Formula

C54H70N14O8S2

Molecular Weight

1107.35

References & Citations

[1]Nafie MS, et al. Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer. Bioorg Chem. 2022; 122:105708.