CB-6673567

CB-6673567 is a selective AC1 inhibitor with an IC50 of 77 μM .CB-6673567blocks the choline-induced cAMP increase and can be used for cardiovascular diseases research[1].

Product Specifications

CAS Number

[379218-90-3]

UNSPSC

12352005

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cb-6673567.html

Smiles

OC1=C2OCOC2=CC=C1C3=NNC=C3C4=CN(C5=CC=CC=C5)N=C4

Molecular Formula

C19H14N4O3

Molecular Weight

346.34

References & Citations

[1]Brand CS, et al. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347 (2) :265-75.|[2]Cheng Q, et al. Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons. Neuropharmacology. 2015 Aug;95:405-14.