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Fraxinellone (Standard)

Fraxinellone (Standard) is the analytical standard of Fraxinellone. This product is intended for research and analytical applications. Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1[1].

Product Specifications

CAS Number

28808-62-0

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; PD-1/PD-L1; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fraxinellone-standard.html

Smiles

O=C1O[C@@H](C2=COC=C2)[C@]3(C)CCCC(C)=C31

Molecular Formula

C14H16O3

Molecular Weight

232.28

References & Citations

[1]Xing Y, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018 Sep;135:166-180.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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