DFAME

DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm) . DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (Kd = 460 nM) and Corn-DFAME (Kd = 3600 nM) . Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research[1].

Product Specifications

CAS Number

[1420815-55-9]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dfame.html

Purity

98.58

Solubility

10 mM in DMSO

Smiles

O=C(OC)/C=C\C1=N/C(C(N1C)=O)=C/C2=CC(F)=C(O)C(F)=C2

Molecular Formula

C15H12F2N2O4

Molecular Weight

322.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiahui Wu, et al. Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers. J Am Chem Soc. 2022 Mar 30;144 (12) :5471-5477.