ML356
ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC50 of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC50 of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma[1].
Product Specifications
CAS Number
1808260-45-8
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml356.html
Smiles
O=C(C(CC)CC)NC1=NC(C2=CC=C(S(=O)(N3CCOCC3)=O)C=C2)=CS1
Molecular Formula
C19H25N3O4S2
Molecular Weight
423.55
References & Citations
[1]Cosford N, et al., Small molecule fatty acid synthase inhibitors. WO2015134790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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