Liriodenine
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].
Product Specifications
CAS Number
[475-75-2]
Product Name Alternative
Spermatheridine; VLT045
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/liriodenine.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53
Molecular Formula
C17H9NO3
Molecular Weight
275.26
Precautions
H301, H311, H331
References & Citations
[1]Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol|[2]Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug Des Devel Ther
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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