Galegine (hydrochloride)
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2].
Product Specifications
CAS Number
[2368870-39-5]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Bacterial
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/galegine-hydrochloride.html
Purity
98.45
Solubility
DMSO : 5.2 mg/mL (ultrasonic) |H2O : 43.33 mg/mL (ultrasonic)
Smiles
NC(NC/C=C(C)\C)=N.[H]Cl
Molecular Formula
C6H14ClN3
Molecular Weight
163.65
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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