Galegine (hydrochloride)

Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2].

Product Specifications

CAS Number

[2368870-39-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/galegine-hydrochloride.html

Purity

98.45

Solubility

DMSO : 5.2 mg/mL (ultrasonic) |H2O : 43.33 mg/mL (ultrasonic)

Smiles

NC(NC/C=C(C)\C)=N.[H]Cl

Molecular Formula

C6H14ClN3

Molecular Weight

163.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Mooney MH, et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br J Pharmacol. 2008 Apr;153 (8) :1669-77.|[2]Coqueiro A, et al. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. J Nat Prod. 2014 Aug 22;77 (8) :1972-5.