Chelerythrine (chloride)

Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.

Product Specifications

CAS Number

[3895-92-9]

UNSPSC

12352005

Hazard Statement

H300, H315, H319, H335

Target

Apoptosis; Autophagy; Bcl-2 Family; PKC

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Chelerythrine-Chloride.html

Purity

99.11

Solubility

DMSO : 4.35 mg/mL (ultrasonic)

Smiles

C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]

Molecular Formula

C21H18ClNO4

Molecular Weight

383.82

Precautions

H300, H315, H319, H335

References & Citations

[1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.|[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19 (10) :890-5. Epub 2012 May 14.|[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11 (6) :3917-3924|[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172 (3) :993-9.|[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278 (23) :20453-6.|[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.