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D-KLA Peptide

D-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase) . d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects[1][2].

Product Specifications

CAS Number

[286380-05-0]

Product Name Alternative

D- (KLAKLAK) 2

UNSPSC

12352209

Target

Caspase; Mitochondrial Metabolism; PARP

Type

Peptides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d-kla-peptide.html

Purity

99.33

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](N)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](C)C(N[C@@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C72H138N20O15

Molecular Weight

1523.99

References & Citations

[1]Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32 (22) : 5262-5268.|[2]Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D- (KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6 (3) : 971-977.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P10285/d-KLA-Peptide-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P10285/d-KLA-Peptide-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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