N-Demethyl Mifepristone

N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683) . The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone[1].

Product Specifications

CAS Number

[104004-96-8]

Product Name Alternative

RU 42633

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Drug Metabolite; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/n-demethyl-mifepristone.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@@]2(O)C#CC)([H])[C@@]3([H])C([C@@H](C4=CC=C(C=C4)NC)C1)=C5C(CC3)=CC(CC5)=O

Molecular Formula

C28H33NO2

Molecular Weight

415.57

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Nguyen D, et al. Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men. Adv Ther. 2017 Oct;34 (10) :2371-2385.