GCase modulator-1
GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM) [1].
Product Specifications
CAS Number
[796079-91-9]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gcase-modulator-1.html
Purity
97.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2=NC3=C(C(N4CC5=C(CC4)C=CC=C5)=N2)C=CC=C3)=CN=CC=C1
Molecular Formula
C22H18N4
Molecular Weight
338.41
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62 (3) :1218-1230.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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