Abiraterone metabolite 1
Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
Product Specifications
CAS Number
[1940176-03-3]
Product Name Alternative
3β-OH-5α-Abi
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Abiraterone_metabolite_1.html
Purity
99.59
Solubility
DMSO : ≥ 25 mg/mL
Smiles
C[C@@]12C(C3=CN=CC=C3)=CC[C@]1([C@@]4(CC[C@@]5([H])[C@@](C)([C@]4(CC2)[H])CC[C@@H](C5)O)[H])[H]
Molecular Formula
C24H33NO
Molecular Weight
351.53
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Li Z, et al. Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy. Nature. 2016 May 26;533 (7604) :547-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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